各种抗血栓形成药物在微血管手术中的作用。

The role of various antithrombotic agents in microvascular surgery.

作者信息

Buckley R C, Davidson S F, Das S K

机构信息

Department of Surgery, University of Mississippi Medical Center.

出版信息

Br J Plast Surg. 1994 Jan;47(1):20-3. doi: 10.1016/0007-1226(94)90112-0.

DOI:10.1016/0007-1226(94)90112-0

PMID:8124561

Abstract

The ultimate goal in microvascular surgery is to achieve improved patency rates while reducing complications of systemic antithrombotic agents. Using a described model of microarterial thrombosis, the antithrombotic effects of oral aspirin (ASA) were assessed in rats. ASA-treated animals (30 mg/kg orally) exhibited significantly prolonged mean bleeding times 1 h and 24 h after dosing when compared to controls (p < 0.01). Platelet aggregation profiles also displayed an inhibition of platelet aggregation in the ASA group relative to controls. In the thrombosis model, however, patency rates were significantly improved at 20 min, but all vessels were thrombosed at 24 h.

摘要

微血管手术的最终目标是提高血管通畅率，同时减少全身抗血栓药物的并发症。使用一种已描述的微动脉血栓形成模型，在大鼠中评估了口服阿司匹林（ASA）的抗血栓作用。与对照组相比，给予ASA治疗的动物（口服30mg/kg）在给药后1小时和24小时的平均出血时间显著延长（p<0.01）。血小板聚集曲线也显示，ASA组相对于对照组对血小板聚集有抑制作用。然而，在血栓形成模型中，20分钟时血管通畅率显著提高，但24小时时所有血管均形成血栓。