Cooley B C, Ruas E J, Wilgis E F
Microsurgery. 1987;8(1):11-6. doi: 10.1002/micr.1920080105.
A model of vascular trauma and subsequent reanastomosis with poor postoperative likelihood of patency was developed in the rat femoral artery. Patency rates were significantly improved with intravenous heparin, intragastric aspirin, and both agents together. Heparin yielded higher patency than aspirin. Intimal surfaces of the vessels at various postoperative intervals were observed with the scanning electron microscope. More fibrin accumulation was seen in the aspirin-treated animals, while more platelet aggregation was found in the heparin-treated group. Both platelet aggregation and fibrin strand development appeared retarded with both agents administered. All groups demonstrated good healing of the ruptured intimal surfaces, beginning at 2 days postoperatively. It is concluded that fibrin strand development is a more significant factor in microvascular occlusion than platelet aggregation.
在大鼠股动脉中建立了一种血管创伤及随后进行再吻合术但术后通畅可能性不佳的模型。静脉注射肝素、胃内给予阿司匹林以及两者联合使用均显著提高了通畅率。肝素的通畅率高于阿司匹林。在术后不同时间间隔用扫描电子显微镜观察血管的内膜表面。在阿司匹林治疗的动物中观察到更多的纤维蛋白积聚，而在肝素治疗组中发现更多的血小板聚集。同时给予两种药物时，血小板聚集和纤维蛋白链形成均似乎受到抑制。所有组在术后2天开始均显示破裂内膜表面愈合良好。得出的结论是，在微血管闭塞中，纤维蛋白链形成比血小板聚集是更重要的因素。
