Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes.
作者信息
von Eitzen U, Meier-Tackmann D, Agarwal D P, Goedde H W
机构信息
Institute of Human Genetics, University of Hamburg, Germany.
出版信息
Cancer Lett. 1994 Jan 15;76(1):45-9. doi: 10.1016/0304-3835(94)90132-5.
PMID:8124665
Abstract
In in vitro studies, no turnover of aldophosphamide and mafosfamide was observed with the tumor-specific aldehyde dehydrogenase 3 isozyme (ALDH3) isolated from human stomach mucosa as well as from lung (A549) and pharynx (UMSCC2) carcinoma cell lines. Only the human liver cytosolic ALDH preparation (ALDH1) showed any significant oxidation of aldophosphamide and mafosfamide.
摘要
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