Okada H, Koyanagi T, Yamada N
Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Japan.
Chem Pharm Bull (Tokyo). 1994 Jan;42(1):57-61. doi: 10.1248/cpb.42.57.
Various benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. All of the prodrugs were soluble in most organic solvents and showed good antitumor activities against P388 leukemia cells in mice when dosed intraperitoneally or orally.
合成了各种苯甲酰基苯基脲衍生物作为候选前药，并在体内检测了它们对P388白血病的抗肿瘤活性。所有前药都可溶于大多数有机溶剂，当腹腔注射或口服给药时，对小鼠P388白血病细胞显示出良好的抗肿瘤活性。
