75千道尔顿肌醇多磷酸-5-磷酸酶（INPP5B）在人类染色体1p34带上的定位

Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34.

作者信息

Jänne P A, Dutra A S, Dracopoli N C, Charnas L R, Puck J M, Nussbaum R L

机构信息

Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia.

出版信息

Cytogenet Cell Genet. 1994;66(3):164-6. doi: 10.1159/000133691.

DOI:10.1159/000133691

PMID:8125013

Abstract

The 75-kDa (type II) inositol polyphosphate-5-phosphatase, originally described in platelets, is one of at least three known enzymes capable of dephosphorylating inositol-1,4,5-trisphosphate (IP3) to inositol-1,4-bisphosphate (IP2). To further characterize these enzymatic forms, we have mapped the gene (INPP5B) coding for the 75-kDa type II enzyme. Using a combination of human x rodent somatic cell hybrids and fluorescence in situ hybridization, we have determined that this gene maps to human chromosome band 1p34.

摘要

最初在血小板中发现的75 kDa（II型）肌醇多磷酸-5-磷酸酶，是已知的至少三种能够将肌醇-1,4,5-三磷酸（IP3）去磷酸化为肌醇-1,4-二磷酸（IP2）的酶之一。为了进一步表征这些酶形式，我们绘制了编码75 kDa II型酶的基因（INPP5B）图谱。通过结合使用人-啮齿动物体细胞杂种和荧光原位杂交技术，我们确定该基因定位于人类染色体1p34带。