Koga H, Miyazaki Y, Kohno S, Hara K
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Kekkaku. 1994 Feb;69(2):113-8.
A drug delivery system (DDS) for the treatment of infectious disease has recently been developed. Since liposomal antimicrobial agents are effective on cytozoic bacteria, we applied liposomal streptomycin and amikacin for the treatment of systemic mycobacterial tuberculosis in mice. Liposomal aminoglycosides showed excellent efficacy compared to free aminoglycosides or empty liposome. This therapeutic strategy should be developed for clinical application. Although the human defense mechanism against microbial infection is very complicated, biological response modifiers (BRM) such as vaccination or cytokine therapy have been investigated. One of the most useful and protective vaccines for prevention of tuberculosis is the Mycobacterium vaccae vaccine, developed by Stanford et al. As for the cytokines, interleukin-2, granulocyte macrophage-colony stimulating factor, and tumor necrosis factor have very strong antimycobacterial activity. Interferon alone, however, has weak efficacy, and should be combined with other effective cytokines. These BRM constitute an excellent strategy for antimycobacterial chemotherapy.
一种用于治疗传染病的药物递送系统（DDS）最近已被开发出来。由于脂质体抗菌剂对胞内细菌有效，我们将脂质体链霉素和阿米卡星应用于小鼠系统性分枝杆菌结核病的治疗。与游离氨基糖苷类药物或空脂质体相比，脂质体氨基糖苷类药物显示出优异的疗效。这种治疗策略应进一步开发用于临床应用。尽管人类对抗微生物感染的防御机制非常复杂，但诸如疫苗接种或细胞因子疗法等生物反应调节剂（BRM）已得到研究。用于预防结核病的最有用且具保护性的疫苗之一是由斯坦福等人开发的母牛分枝杆菌疫苗。至于细胞因子，白细胞介素 -2、粒细胞巨噬细胞集落刺激因子和肿瘤坏死因子具有非常强的抗分枝杆菌活性。然而，单独的干扰素疗效较弱，应与其他有效细胞因子联合使用。这些生物反应调节剂构成了抗分枝杆菌化疗的优秀策略。
