White V, Canfield D V, Hordinsky J
Toxicology and Accident Research Laboratory, Federal Aviation Administration, Department of Transportation, Oklahoma City, OK 73125-5066.
J Anal Toxicol. 1994 Jan-Feb;18(1):52-3. doi: 10.1093/jat/18.1.52.
Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base-extraction procedures, and the parent drug is unsuitable for analysis using gas chromatography. In this case, a thin-layer chromatography solvent system and high-performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by high-performance liquid chromatography.
氨苯蝶啶是一种利尿药物，常与其他药物联合用于治疗高血压。在一名飞机失事遇难者的血液和尿液中发现了氨苯蝶啶。氨苯蝶啶的提取和鉴定存在困难。使用一些标准的碱提取程序时，其提取效率较低，且母体药物不适合用气相色谱法进行分析。在本案例中，采用薄层色谱溶剂系统和高效液相色谱法对血液和尿液中的氨苯蝶啶进行鉴定和定量。氨苯蝶啶在紫外区域是强吸收剂，具有独特的紫外光谱，这使得通过高效液相色谱法对该物质进行鉴定和定量变得更加简便。
