Reale D, Guarino M, Bianchini E, Crescini C, Pascale M, Mazzolari M, Micoli G
Pathologica. 1993 Sep-Oct;85(1099):525-32.
Authors report a case of alveolar variant of infiltrating lobular carcinoma of the breast with stromal osteoclast-like giant cells. Immunohistochemically the carcinoma cells were reactive for EMA and Cytokeratins; osteoclast-like giant cells (OCL-GC) were negative. OCL-GC and histiocytoid mononuclear cells with nuclei similar to those within the OCL-GC present in this case, were strongly immunoreactive with KP-1, a recently developed monoclonal antibody directed against cells of mononuclear phagocytic lineage in routinely processed tissue section and showed immunoreactivity to vimentin. These findings of our case provide evidence against a carcinoma cells derivation and support a monocytic/histiocytic origin for the OCL-GC.
作者报告了1例乳腺浸润性小叶癌肺泡变型伴基质破骨细胞样巨细胞的病例。免疫组化显示癌细胞对上皮膜抗原（EMA）和细胞角蛋白呈阳性反应；破骨细胞样巨细胞（OCL-GC）呈阴性。本病例中的OCL-GC以及细胞核与OCL-GC内细胞核相似的组织细胞样单核细胞，与KP-1呈强免疫反应，KP-1是一种最近开发的针对常规处理组织切片中单核吞噬细胞系细胞的单克隆抗体，且对波形蛋白呈免疫反应。我们病例的这些发现提供了反对癌细胞起源的证据，并支持OCL-GC的单核细胞/组织细胞起源。
