• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硫代磷酸酯-甲基膦酸酯寡核苷酸共聚物的合成。

Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.

作者信息

Zhou L, Morocho A M, Chen B C, Cohen J S

机构信息

Pharmacology Department, Georgetown University Medical Center, Washington, DC 20007.

出版信息

Nucleic Acids Res. 1994 Feb 11;22(3):453-6. doi: 10.1093/nar/22.3.453.

DOI:10.1093/nar/22.3.453
PMID:8127684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC523603/
Abstract

We describe the synthesis and characterization of novel phosphorothioate-methylphosphonate backbone-modified oligodeoxynucleotide co-polymers. These may have potential use as antisense constructs.

摘要

我们描述了新型硫代磷酸酯-甲基膦酸酯主链修饰的寡脱氧核苷酸共聚物的合成与表征。这些共聚物可能具有作为反义构建体的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ff8/523603/638378df20cc/nar00027-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ff8/523603/638378df20cc/nar00027-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ff8/523603/638378df20cc/nar00027-0210-a.jpg

相似文献

1
Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.硫代磷酸酯-甲基膦酸酯寡核苷酸共聚物的合成。
Nucleic Acids Res. 1994 Feb 11;22(3):453-6. doi: 10.1093/nar/22.3.453.
2
Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates).合成寡聚（脱氧核糖核苷硫代磷酸酯）的新途径。P-手性寡聚（脱氧核糖核苷硫代磷酸酯）的立体控制合成。
Nucleic Acids Res. 1991 Nov 11;19(21):5883-8. doi: 10.1093/nar/19.21.5883.
3
Synthesis and selective cleavage of an oligodeoxynucleotide containing a bridged internucleotide 5'-phosphorothioate linkage.
Nucleic Acids Res. 1991 Apr 11;19(7):1437-41. doi: 10.1093/nar/19.7.1437.
4
Solid phase synthesis of oligodeoxyribonucleoside phosphorodithioates from thiophosphoramidites.由硫代磷酰胺酯固相合成寡聚脱氧核糖核苷二硫代磷酸酯
Nucleic Acids Res. 1991 Nov 11;19(21):5843-50. doi: 10.1093/nar/19.21.5843.
5
On the rapid deprotection of synthetic oligonucleotides and analogs.关于合成寡核苷酸及其类似物的快速脱保护
Nucleic Acids Res. 1994 Feb 25;22(4):639-45. doi: 10.1093/nar/22.4.639.
6
Optimized synthesis of phosphorothioate oligodeoxyribonucleotides substituted with a 5'-protected thiol function and a 3'-amino group.5'-端带有保护硫醇功能基团且3'-端带有氨基的硫代磷酸酯寡脱氧核糖核苷酸的优化合成。
Nucleic Acids Res. 2000 Feb 1;28(3):818-25. doi: 10.1093/nar/28.3.818.
7
New efficient sulfurizing reagents for the preparation of oligodeoxyribonucleotide phosphorothioate analogues.用于制备寡脱氧核糖核苷酸硫代磷酸酯类似物的新型高效硫化试剂。
Nucleic Acids Res. 1995 Oct 25;23(20):4029-33. doi: 10.1093/nar/23.20.4029.
8
Ion-exchange high-performance liquid chromatography analysis of oligodeoxyribonucleotide phosphorothioates.
Anal Biochem. 1992 Feb 1;200(2):342-6. doi: 10.1016/0003-2697(92)90476-n.
9
Synthesis and nuclease susceptibility of alpha-oligodeoxyribonucleotide phosphorothioate.α-寡脱氧核糖核苷酸硫代磷酸酯的合成及核酸酶敏感性
Nucleic Acids Symp Ser. 1991(25):101-2.
10
Synthesis and anti-HIV activity of oligoribonucleotides and their phosphorothioate analogs.
Ann N Y Acad Sci. 1992 Oct 28;660:2-10. doi: 10.1111/j.1749-6632.1992.tb21052.x.

引用本文的文献

1
Radiolabeled oligonucleotides for antisense imaging.用于反义成像的放射性标记寡核苷酸。
Curr Org Synth. 2011 Aug 1;8(4):604-614. doi: 10.2174/157017911796117241.
2
Preclinical and clinical pharmacology of antisense oligonucleotides.反义寡核苷酸的临床前和临床药理学
Mol Biotechnol. 1999 Aug;12(1):1-11. doi: 10.1385/MB:12:1:1.

本文引用的文献

1
Phosphorothioate-phosphodiester oligonucleotide co-polymers: assessment for antisense application.硫代磷酸酯-磷酸二酯寡核苷酸共聚物：反义应用评估
Anticancer Drug Des. 1993 Feb;8(1):15-32.
2
Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support.在聚苯乙烯载体上制备寡脱氧核糖核苷甲基膦酸酯。
Nucleic Acids Res. 1983 Sep 24;11(18):6225-42. doi: 10.1093/nar/11.18.6225.
3
Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.
寡脱氧核苷酸的硫代磷酸酯类似物：人类免疫缺陷病毒复制及细胞病变效应的抑制剂
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7706-10. doi: 10.1073/pnas.84.21.7706.
4
A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression).一种基于分子生物学和核酸化学的化疗新方法：Matagen（基因表达遮蔽带）
Anticancer Drug Des. 1987 Oct;2(2):117-28.
5
Physicochemical properties of phosphorothioate oligodeoxynucleotides.硫代磷酸酯寡脱氧核苷酸的物理化学性质。
Nucleic Acids Res. 1988 Apr 25;16(8):3209-21. doi: 10.1093/nar/16.8.3209.
6
RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds.核糖核酸酶H对与含有甲基膦酸酯、硫代磷酸酯和磷酸二酯键的寡核苷酸杂交的RNA的切割作用。
Nucleic Acids Res. 1989 Nov 25;17(22):9193-204. doi: 10.1093/nar/17.22.9193.
7
Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection.硫代磷酸酯封端对反义寡核苷酸稳定性、杂交以及针对单纯疱疹病毒感染的抗病毒效力的影响。
Nucleic Acids Res. 1991 Oct 25;19(20):5743-8. doi: 10.1093/nar/19.20.5743.
8
Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages.含甲基膦酸酯键的修饰寡脱氧核苷酸的细胞摄取机制。
Nucleic Acids Res. 1991 Oct 25;19(20):5543-50. doi: 10.1093/nar/19.20.5543.
9
Oligodeoxynucleotides as antisense inhibitors of gene expression.
Prog Nucleic Acid Res Mol Biol. 1992;42:79-126. doi: 10.1016/s0079-6603(08)60574-7.
10
Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells.硫代磷酸酯寡核苷酸在培养细胞中的细胞摄取及亚细胞分布
Antisense Res Dev. 1992 Fall;2(3):211-22. doi: 10.1089/ard.1992.2.211.