Cairns B R, Kim Y J, Sayre M H, Laurent B C, Kornberg R D
Department of Cell Biology, Stanford University School of Medicine, CA 94305.
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1950-4. doi: 10.1073/pnas.91.5.1950.
A complex containing the products of the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 genes and four additional polypeptides has been purified from extracts of the yeast Saccharomyces cerevisiae. Physical association of these proteins was demonstrated by copurification and coimmunoprecipitation. A potent DNA-dependent ATPase copurified with the complex, and this activity was evidently associated with SWI2/SNF2.
一种包含SWI1/ADR6、SWI2/SNF2、SWI3、SNF5和SNF6基因产物以及另外四种多肽的复合物已从酿酒酵母提取物中纯化出来。这些蛋白质通过共纯化和共免疫沉淀证明存在物理关联。一种强效的依赖DNA的ATP酶与该复合物共纯化，并且这种活性显然与SWI2/SNF2相关。
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