Lee K F, Bachman K, Landis S, Jaenisch R
Whitehead Institute for Biomedical Research, Cambridge, MA.
Science. 1994 Mar 11;263(5152):1447-9. doi: 10.1126/science.8128229.
The low-affinity neurotrophin receptor p75 binds all neurotrophins with similar affinity. For elucidation of its function, mice bearing a null mutation in the p75 locus were generated. Examination of sympathetic innervation of target tissues revealed that pineal glands lacked innervation and sweat gland innervation was absent or reduced in particular footpads. The absence of adult innervation reflects the failure of axons to reach these targets during development rather than a target deficit. These results indicate that p75 facilitates development of specific populations of sympathetic neurons, for which it may support axon growth.
低亲和力神经营养因子受体p75以相似的亲和力结合所有神经营养因子。为阐明其功能，构建了p75基因座存在无效突变的小鼠。对靶组织的交感神经支配进行检查发现，松果体缺乏神经支配，并且特定脚垫中的汗腺神经支配缺失或减少。成年后缺乏神经支配反映出发育过程中轴突未能到达这些靶标，而非靶标缺陷。这些结果表明，p75促进特定交感神经元群体的发育，它可能为此支持轴突生长。
