Conlan M G, Folsom A R, Finch A, Davis C E, Sorlie P, Wu K K
Division of Hematology and Vascular Biology Research Center, University of Texas Medical School, Houston 77030.
Thromb Haemost. 1993 Nov 15;70(5):762-7.
To evaluate the association of plasma protein C levels with constitutional, socioeconomic, life-style and biochemical factors important in cardiovascular diseases, we measured protein C levels in 12,290 middle aged (45-64 years) subjects participating in the ARIC study. Protein C levels had a normal distribution with a mean value of 3.17 micrograms/ml. They were higher in women than men and in whites than blacks; higher in postmenopausal women and further increased by hormonal supplements. The age influence was inconsistent and was considered to be inconsequential. Protein C levels were positively correlated with body mass index, LDL-cholesterol, HDL-cholesterol, and triglycerides and negatively associated with cigarette smoking. These factors should be taken into consideration when establishing normal protein C levels and when analyzing the relation between protein C and arterial and venous thrombotic disorders.
为评估血浆蛋白C水平与心血管疾病中重要的体质、社会经济、生活方式及生化因素之间的关联，我们在参与动脉粥样硬化风险社区（ARIC）研究的12290名中年（45 - 64岁）受试者中测量了蛋白C水平。蛋白C水平呈正态分布，均值为3.17微克/毫升。女性的蛋白C水平高于男性，白人高于黑人；绝经后女性的蛋白C水平更高，且激素补充剂会使其进一步升高。年龄的影响不一致，被认为无关紧要。蛋白C水平与体重指数、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及甘油三酯呈正相关，与吸烟呈负相关。在确定正常蛋白C水平以及分析蛋白C与动脉和静脉血栓形成疾病之间的关系时，应考虑这些因素。
