Orfanos C E, Künzig M
Hautarzt. 1975 Nov;26(11):581-4.
Chronic lead nephtropathy, secondary gout (lead-gout) and porphyrinuria may develop after long lasting professional exposure to lead. A printer with giant tophi on his hands and feet excreted a significantly higher amount of lead after infusion of calcium EDTA in comparison with a normal control person. This result indicates an increased mobilization of lead from skeletal deposits. Furthermore, the laboratory findings showed renal insufficency and porphyrinuria up to 1316 mug/l (elevation of total porphyrins with slight or no elevation of delta-amino-levulic acid and porphobilinogene). The clinical triad nephropathy, secondary gout and porphyrinuria seems to be a variant of chronic lead poisoning.
长期职业性接触铅后可能会发生慢性铅肾病、继发性痛风（铅性痛风）和卟啉尿症。一名手脚患有巨大痛风石的印刷工人在输注依地酸钙后，其排出的铅量明显高于正常对照者。这一结果表明骨骼沉积物中铅的动员增加。此外，实验室检查结果显示肾功能不全，卟啉尿高达1316微克/升（总卟啉升高，δ-氨基-γ-酮戊酸和胆色素原轻度升高或无升高）。肾病、继发性痛风和卟啉尿三联征似乎是慢性铅中毒的一种变体。
