[前列腺癌根治术的临床研究]

[Clinical study of total prostatectomy for prostatic cancer].

作者信息

Fujii A, Gohji K, Morisue K, Maruyama S, Kizaki T, Oka N

机构信息

Department of Urology, Hyogo Medical Center for Adults.

出版信息

Hinyokika Kiyo. 1994 Feb;40(2):111-7.

PMID:8128919

Abstract

Total retropubic prostatectomy was performed on 31 patients with prostatic cancer (median age; 70 years). The accuracy of staging was 55% (17 patients). In 11 patients (35%) the staging had been underestimated, and in 3 patients (10%) overestimated. The pathological stage and grade were stage B in 14 patients, stage C in 4 patients, stage D1 in 13 patients (pN1; 8 patients, pN2; 5 patients), well differentiated adenocarcinoma (WDA) in 8 patients moderately differentiated adenocarcinoma (MDA) in 7 patients, and poorly differentiated adenocarcinoma (PDA) in 16 patients. The WDA were all stage B, and 85% of the PDA were stage D1. The positive surgical margin rate was 21% in stage B, 50% in stage C, 85% in stage D1, 13% in WDA, 43% in MDA, and 75% in PDA. Five of the patients died, and the causes of death were prostatic cancer in 2 patients (pN2/PDA), and others in 3 patients (1 patient; stage B/PDA, 2 patients; pN2/PDA). The 5-year survival rate (Kaplan-Meier) was 84% on the whole, 83% for stage B, 100% for stage C, 83% for stage D1, 100% for WDA, 100% for MDA, 71% for PDA, 86% for pN0, 100% for pN1, and 38% for pN2.

摘要

对31例前列腺癌患者（中位年龄70岁）实施了耻骨后前列腺切除术。分期准确率为55%（17例患者）。11例患者（35%）分期被低估，3例患者（10%）分期被高估。病理分期和分级为：14例患者为B期，4例患者为C期，13例患者为D1期（pN1；8例患者，pN2；5例患者）；8例患者为高分化腺癌（WDA），7例患者为中分化腺癌（MDA），16例患者为低分化腺癌（PDA）。高分化腺癌均为B期，85%的低分化腺癌为D1期。B期患者手术切缘阳性率为21%，C期为50%，D1期为85%，高分化腺癌为13%，中分化腺癌为43%，低分化腺癌为75%。5例患者死亡，死亡原因：2例患者死于前列腺癌（pN2/PDA），3例患者死于其他原因（1例患者；B期/PDA，2例患者；pN2/PDA）。总体5年生存率（Kaplan-Meier法）为84%，B期为83%，C期为100%，D1期为83%，高分化腺癌为100%，中分化腺癌为100%，低分化腺癌为71%，pN0为86%，pN1为100%，pN2为38%。