色甘酸钠粉治疗豚草花粉症的效果。
The effect of cromolyn sodium powder as a treatment for ragweed pollinosis.
作者信息
Leiferman K M, Yunginger J W, Larson J B, Gleich G J
出版信息
J Allergy Clin Immunol. 1975 Dec;56(6):481-90. doi: 10.1016/0091-6749(75)90066-4.
The effect of treating ragweed pollinosis with intranasal cromolyn sodium powder was evaluated in 26 patients in a double-blind clinical study. Thirteen matched patient pairs were treated by either nasal insufflation of cromolyn sodium powder, 20 mg three times daily, or by a placebo powder. Patients were monitored for severity of symptoms by means of daily symptom diaries collected weekly throughout the pollen season. Serum samples were obtained in July prior to the ragweed season and following the ragweed season during the first and fourth weeks of October for the determination of ragweed-specific IgE antibody levels by the radioallergosorbent test. A significant reduction in symptom severity was observed in the treated patients with high preseasonal levels of IgE antibody to ragweed. Initially the levels of IgE antibody to ragweed did not differ between the two groups. IgE antibody levels increased in both groups after pollen exposure, but the treated group showed a significantly greater rise in IgE antibody levels. The results suggest that treatment with cromolyn sodium enhanced IgE antibody response to pollen exposure and significantly reduced the severity of hay fever symptoms in patients with high preseasonal levels of IgE antibody to ragweed.
在一项双盲临床研究中，对26例患者评估了鼻内使用色甘酸钠粉末治疗豚草花粉症的效果。13对匹配的患者分别接受每日3次、每次20毫克色甘酸钠粉末鼻腔给药或安慰剂粉末治疗。在整个花粉季节，通过每周收集的每日症状日记监测患者症状的严重程度。在豚草季节开始前的7月以及10月第一周和第四周的豚草季节结束后采集血清样本，通过放射变应原吸附试验测定豚草特异性IgE抗体水平。在花粉季节前对豚草IgE抗体水平较高的治疗患者中，观察到症状严重程度显著降低。最初，两组之间豚草IgE抗体水平没有差异。花粉暴露后两组的IgE抗体水平均升高，但治疗组的IgE抗体水平升高幅度明显更大。结果表明，色甘酸钠治疗可增强对花粉暴露的IgE抗体反应，并显著降低花粉季节前豚草IgE抗体水平较高患者的花粉症症状严重程度。
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