Li J K, Zhu Y
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey.
Angiology. 1994 Feb;45(2):113-7. doi: 10.1177/000331979404500205.
Arterial compliance has been recognized to be pressure-dependent. Its variation due to changing systolic and diastolic blood pressures in hypertension and subsequent vasodilation has not been investigated. The authors examined this aspect by combining an animal experiment and a recently established nonlinear windkessel model of the arterial system that incorporates a pressure-dependent arterial compliance, C(P). Aortic pressure and flow were simultaneously measured in experimental dogs during control and during methoxamine-induced hypertension and nitroprusside-induced vasodilation. A numerical procedure was implemented to compute the nonlinear compliance and account for the pressure dependence. Results show that within the cardiac cycle, C(P) reached its maximum at end-systole and increased in diastole when diastolic aortic pressure decayed. The magnitude of C(P) and its variation within the cardiac cycle was larger at low pressures, while the reverse was found when blood pressure was high. C(P) decreased significantly in hypertension and increased during subsequent vasodilation.
动脉顺应性已被认为是压力依赖性的。尚未研究其在高血压中由于收缩压和舒张压变化以及随后的血管舒张所导致的变化。作者通过结合动物实验和最近建立的包含压力依赖性动脉顺应性C(P)的动脉系统非线性风箱模型来研究这一方面。在对照期间以及甲氧明诱导的高血压和硝普钠诱导的血管舒张期间，同时测量实验犬的主动脉压力和血流。实施了一个数值程序来计算非线性顺应性并考虑压力依赖性。结果表明，在心动周期内，C(P)在收缩末期达到最大值，并且在舒张期当主动脉舒张压下降时增加。C(P)的大小及其在心动周期内的变化在低压时较大，而在血压高时则相反。在高血压中C(P)显著降低，而在随后的血管舒张期间增加。
