Alessandri C, Basili S, Maurelli M, Andreozzi P, Colletta A, Paradiso M, Cordova C
Terapia Medica Institute, University of Rome, La Sapienza, Italy.
Angiology. 1994 Feb;45(2):131-6. doi: 10.1177/000331979404500208.
Apolipoprotein (apo) C-II and apo C-III serum concentrations were investigated in 119 normotriglyceridemic male subjects with peripheral arterial disease (PAD) or coronary heart disease (CHD) or without clinical manifestations of atherosclerotic disease. All subjects included in the study had similar blood levels of total cholesterol (< 400 mg/dL). High-density lipoproteins cholesterol (HDL-C) subfractions and apo A-I serum levels were significantly lower in CHD patients, as were apo A-I/apo B and HDL-cholesterol/total cholesterol ratios. Apo C-II and apo C-III showed similar serum concentrations in all three groups of subjects, but apo C-II/apo C-III ratio was significantly lower in PAD patients as compared with that in CHD patients and control subjects. This study confirms that PAD may be associated with a particular lipoprotein derangement that primarily involves very low-density lipoprotein catabolism.
对119名甘油三酯正常的男性受试者进行了研究，这些受试者患有外周动脉疾病（PAD）或冠心病（CHD），或无动脉粥样硬化疾病的临床表现。纳入研究的所有受试者总胆固醇血液水平相似（<400mg/dL）。冠心病患者的高密度脂蛋白胆固醇（HDL-C）亚组分和载脂蛋白A-I血清水平显著较低，载脂蛋白A-I/载脂蛋白B和HDL-胆固醇/总胆固醇比值也是如此。载脂蛋白C-II和载脂蛋白C-III在所有三组受试者中的血清浓度相似，但与冠心病患者和对照组相比，PAD患者的载脂蛋白C-II/载脂蛋白C-III比值显著较低。本研究证实，PAD可能与一种特定的脂蛋白紊乱有关，这种紊乱主要涉及极低密度脂蛋白的分解代谢。
