Hughes B R, Cunliffe W J
Leeds (England) Foundation for Dermatological Research, General Infirmary.
Arch Dermatol. 1994 Mar;130(3):315-8.
A prospective study of 30 patients with moderate to severe acne was performed. The follicular reservoir and sustainable sebum excretion rates were measured before and after a 4-month course of isotretinoin at a dose of 1 mg/kg per day.
The follicular reservoir and sustainable sebum excretion rates were profoundly reduced at the end of the course of isotretinoin (79% and 83%, respectively) and remained significantly suppressed at 1 year following therapy (43% and 36%, respectively). Those patients who relapsed clinically at 1 year after treatment had a significantly higher follicular reservoir rate.
These data support the concept that up to 1 year after therapy, there is a reduction in the sebum secretion rate accompanying the remission of acne. This suppressed sebum secretion may modulate the microenvironment of the pilosebaceous canal through an effect on the follicular reservoir.
对30例中重度痤疮患者进行了一项前瞻性研究。在每天1mg/kg剂量的异维A酸治疗4个月疗程前后，测量毛囊储库和可持续皮脂排泄率。
异维A酸疗程结束时，毛囊储库和可持续皮脂排泄率显著降低（分别为79%和83%），治疗后1年仍受到显著抑制（分别为43%和36%）。治疗后1年临床复发的患者毛囊储库率显著更高。
这些数据支持这样的概念，即治疗后长达1年，皮脂分泌率随痤疮缓解而降低。这种皮脂分泌受抑制可能通过对毛囊储库的影响来调节皮脂腺导管的微环境。
