Drobinski G, Brisset D, Philippe F, Kremer D, Laurian C, Montalescot G, Thomas D
Service de cardiologie, CHU Pitié-Salpêtrière, Paris.
Arch Mal Coeur Vaiss. 1993 Sep;86(9):1331-6.
Ultrasonic energy has been shown to be able to disrupt atherosclerotic plaques and thrombi. The authors used an ultrasonic angioplastic technique developed by the group in 10 patients with a femoral arterial occlusion. The ultrasonic angioplasty was attempted before surgical bypass using a 130 cm long titanium guide wire with a 0.8 mm diameter and a round distal tip measuring 2 or 2.5 mm. Angiographic and angioscopic examinations were performed before and after the procedure in 9 patients. It was not possible to perform the angioplasty in 1 patient. Angioscopy showed that the proximal part of the occlusion consisted of atheromatous material in 3 cases and of thrombus in 6 cases. Angiography showed complete restoration of flow in 4 cases; distal flow was very slow in 4 cases and no distal run-off was observed in 1 case. Angioscopy showed residual stenosis at the site of entry in only 1 case. In 3 cases, the artery had no significant residual stenosis. In the other 5 patients residual stenosis was present and angioscopy showed persistence of strands of fibrin and small thrombi. These results show that ultrasonic angioplasty was capable of recanalising an occlusion in 9 out of 10 patients with partial or total disruption of thrombi. At the present stage of development of this system, balloon angioplasty would be an essential complement in most cases in order to obtain normal flow without significant residual stenosis. The manoeuverability of the guide wire and the relatively small size of the round distal tip explain why not all the thrombi could be treated.(ABSTRACT TRUNCATED AT 250 WORDS)
超声能量已被证明能够破坏动脉粥样硬化斑块和血栓。作者对该研究小组开发的一种超声血管成形技术进行了应用,对象为10例股动脉闭塞患者。在进行外科搭桥手术前,尝试使用一根长130厘米、直径0.8毫米、远端圆形尖端尺寸为2或2.5毫米的钛制导丝进行超声血管成形术。9例患者在手术前后进行了血管造影和血管内镜检查。1例患者无法进行血管成形术。血管内镜检查显示,3例闭塞近端部分由动脉粥样硬化物质组成,6例由血栓组成。血管造影显示,4例血流完全恢复;4例远端血流非常缓慢,1例未观察到远端血流。血管内镜检查仅1例显示入口处有残余狭窄。3例患者动脉无明显残余狭窄。在其他5例患者中存在残余狭窄,血管内镜检查显示有纤维蛋白条索和小血栓持续存在。这些结果表明,超声血管成形术能够使10例患者中的9例闭塞再通,血栓部分或完全被破坏。在该系统目前的发展阶段,球囊血管成形术在大多数情况下将是必不可少的补充手段,以便获得正常血流且无明显残余狭窄。导丝的可操作性以及圆形远端尖端相对较小的尺寸解释了为何并非所有血栓都能得到治疗。(摘要截取自250字)