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1
Convulxin-induced platelet aggregation is accompanied by a powerful activation of the phospholipase C pathway.convulxin诱导的血小板聚集伴随着磷脂酶C途径的强烈激活。
Biochem J. 1994 Feb 15;298 ( Pt 1)(Pt 1):87-91. doi: 10.1042/bj2980087.
2
Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLC gamma 2, independently of integrin alpha IIb beta 3.芋螺毒素通过酪氨酸激酶依赖性途径诱导血小板活化，并刺激血小板蛋白的酪氨酸磷酸化，包括磷脂酶Cγ2，且不依赖于整合素αIIbβ3。
Arch Biochem Biophys. 1998 May 15;353(2):239-50. doi: 10.1006/abbi.1998.0598.
3
cAMP does not inhibit convulxin-induced tyrosyl-phosphorylation of human platelet proteins, including PLCgamma2, but completely blocks the integrin alphaIIb beta3-dependent dephosphorylation step: comparisons with RGDS peptide, cytochalasin D, and phenylarsine oxide.环磷酸腺苷（cAMP）并不抑制convulxin诱导的人血小板蛋白（包括磷脂酶Cγ2（PLCγ2））的酪氨酰磷酸化，但完全阻断整合素αIIbβ3依赖性的去磷酸化步骤：与RGDS肽、细胞松弛素D和氧化苯胂的比较。
Arch Biochem Biophys. 1998 Jun 15;354(2):255-62. doi: 10.1006/abbi.1998.0637.
4
Carrageenan-induced activation of human platelets is dependent on the phospholipase C pathway.角叉菜胶诱导的人血小板激活依赖于磷脂酶C途径。
Br J Haematol. 1993 Feb;83(2):270-5. doi: 10.1111/j.1365-2141.1993.tb08282.x.
5
Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen.磷脂酰肌醇3'-激酶和酪氨酸磷酸酶激活正向调节芋螺毒素诱导的血小板激活。与胶原蛋白的比较。
FEBS Lett. 1999 Apr 1;448(1):95-100. doi: 10.1016/s0014-5793(99)00340-3.
6
Neomycin inhibits inositol phosphate formation in human platelets stimulated by thrombin but not other agonists.新霉素可抑制凝血酶刺激的人血小板中肌醇磷酸的形成，但对其他激动剂无此作用。
FEBS Lett. 1986 Oct 20;207(1):53-7. doi: 10.1016/0014-5793(86)80011-4.
7
Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella.由从南美森林眼镜蛇毒液中提取的一种物质——convulxin诱导的豚鼠血小板激活。
Eur J Pharmacol. 1980 Dec 19;68(4):451-64. doi: 10.1016/0014-2999(80)90420-3.
8
Aggretin, a novel platelet-aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia/IIa agonist.凝集素是一种从红口蝮蛇毒液中提取的新型血小板聚集诱导剂，它通过作为糖蛋白Ia/IIa激动剂来激活磷脂酶C。
Biochem J. 1995 Aug 1;309 ( Pt 3)(Pt 3):1021-7. doi: 10.1042/bj3091021.
9
High-Dose Epinephrine Enhances Platelet Aggregation at the Expense of Procoagulant Activity.大剂量肾上腺素会增强血小板聚集，同时降低促凝活性。
Thromb Haemost. 2021 Oct;121(10):1337-1344. doi: 10.1055/a-1420-7630. Epub 2021 May 13.
10
Translocation-independent activation of protein kinase C by platelet-activating factor, thrombin and prostacyclin. Lack of correlation with polyphosphoinositide hydrolysis in rabbit platelets.血小板激活因子、凝血酶和前列环素对蛋白激酶C的非易位依赖性激活。与兔血小板中多磷酸肌醇水解缺乏相关性。
Biochem J. 1990 May 1;267(3):689-96. doi: 10.1042/bj2670689.

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1
Salivary antigen-5/CAP family members are Cu2+-dependent antioxidant enzymes that scavenge O₂₋. and inhibit collagen-induced platelet aggregation and neutrophil oxidative burst.唾液酸抗原 5/CAP 家族成员是 Cu2+依赖性抗氧化酶，可清除 O₂₋，抑制胶原诱导的血小板聚集和中性粒细胞氧化爆发。
J Biol Chem. 2013 May 17;288(20):14341-14361. doi: 10.1074/jbc.M113.466995. Epub 2013 Apr 5.
2
Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of Chagas disease, binds to TXA(2) but does not interact with glycoprotein PVI.三铂，一种来自恰加斯病传播媒介三锥虫唾液腺的血小板聚集抑制剂，与 TXA(2)结合但不与糖蛋白 PVI 相互作用。
Thromb Haemost. 2012 Jan;107(1):111-23. doi: 10.1160/TH11-10-0685. Epub 2011 Dec 8.
3
A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis.一种新型 RGD 包含的解整合素家族（Tablysin-15）来自马蝇 Tabanus yao 的唾液腺，靶向 αIIbβ3 或 αVβ3，抑制血小板聚集和血管生成。
Thromb Haemost. 2011 Jun;105(6):1032-45. doi: 10.1160/TH11-01-0029. Epub 2011 Apr 7.
4
The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin.磷脂酶C/蛋白激酶C途径参与组织蛋白酶G诱导的人血小板活化：与凝血酶的比较。
Biochem J. 1996 Jan 15;313 ( Pt 2)(Pt 2):401-8. doi: 10.1042/bj3130401.

本文引用的文献

1
Aggregation of blood platelets by adenosine diphosphate and its reversal.二磷酸腺苷引起的血小板聚集及其逆转
Nature. 1962 Jun 9;194:927-9. doi: 10.1038/194927b0.
2
Carrageenan-induced activation of human platelets is dependent on the phospholipase C pathway.角叉菜胶诱导的人血小板激活依赖于磷脂酶C途径。
Br J Haematol. 1993 Feb;83(2):270-5. doi: 10.1111/j.1365-2141.1993.tb08282.x.
3
Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus.convulxin，一种源自南美响尾蛇（Crotalus durissus terrificus）毒液的新毒素。
Toxicon. 1981;19(6):875-87. doi: 10.1016/0041-0101(81)90085-4.
4
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.锂可增强大脑和唾液腺中激动剂依赖性磷脂酰肌醇反应。
Biochem J. 1982 Sep 15;206(3):587-95. doi: 10.1042/bj2060587.
5
Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella.由从南美森林眼镜蛇毒液中提取的一种物质——convulxin诱导的豚鼠血小板激活。
Eur J Pharmacol. 1980 Dec 19;68(4):451-64. doi: 10.1016/0014-2999(80)90420-3.
6
Convulxin-induced activation of intact and of thrombin-degranulated rabbit platelets: specific crossed desensitisation with collagen.芋螺毒素诱导的完整及经凝血酶脱颗粒的兔血小板激活：与胶原蛋白的特异性交叉脱敏作用
Eur J Pharmacol. 1983 Aug 19;92(1-2):57-68. doi: 10.1016/0014-2999(83)90108-5.
7
I--isolation and electron microscope studies of a potent platelet-aggregating glycoprotein from the venom of Crotalus durissus cascavella.I——关于从多斑响尾蛇毒液中分离出一种强效血小板聚集糖蛋白及其电子显微镜研究。
Biochimie. 1983 Jul;65(7):405-16. doi: 10.1016/s0300-9084(83)80060-1.
8
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.1,4,5-三磷酸肌醇促使胰腺腺泡细胞非线粒体胞内钙库释放钙离子。
Nature. 1983;306(5938):67-9. doi: 10.1038/306067a0.
9
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.凝血酶刺激的血小板中磷脂酰肌醇4,5-二磷酸的快速减少。
J Biol Chem. 1982 Nov 10;257(21):12705-8.
10
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.红细胞膜的多磷酸肌醇磷酸二酯酶
Biochem J. 1981 Jul 15;198(1):133-40. doi: 10.1042/bj1980133.

convulxin诱导的血小板聚集伴随着磷脂酶C途径的强烈激活。

Convulxin-induced platelet aggregation is accompanied by a powerful activation of the phospholipase C pathway.

作者信息

Faili A, Randon J, Francischetti I M, Vargaftig B B, Hatmi M

机构信息

Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur-INSERM U285, Paris, France.

出版信息

Biochem J. 1994 Feb 15;298 ( Pt 1)(Pt 1):87-91. doi: 10.1042/bj2980087.

DOI:10.1042/bj2980087
PMID:8129734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137986/
Abstract

Platelet aggregation and stimulation of phosphoinositide-specific phospholipase C (PLC) by thrombin and by convulxin (Cvx), a non-enzymic snake venom glycoprotein, were compared. Cvx-stimulated production of inositol phosphates by washed platelets was independent of the cyclo-oxygenase pathway, formation of platelet-activating factor and ADP release, but prostacyclin (prostaglandin I2), a stimulator of cyclic AMP formation, suppressed its effects on platelet and PLC activation. Kinetic analysis showed that inositol 1,4,5-trisphosphate formation reached its maximal value 15 s after platelet stimulation with Cvx and persisted for at least 5 min. Neomycin sulphate (10 mM), which complexes phosphatidylinositol 4-phosphate and phosphatidyl-inositol 4,5-bisphosphate, decreased the production of inositol phosphates, partially prevented platelet aggregation induced by a high concentration of Cvx (10 nM) and abolished both platelet aggregation and inositol phosphate formation induced by thrombin (2 units/ml) and by a stable prostaglandin H2 analogue, U46619 (1 microM). In contrast with neomycin sulphate, Na2SO4 had no significant effect against all agonists tested. It is concluded that platelet activation by Cvx is partially mediated by PLC and involves other mechanisms as well.

摘要

比较了凝血酶和convulxin（Cvx，一种非酶蛇毒糖蛋白）对血小板聚集以及对磷酸肌醇特异性磷脂酶C（PLC）的刺激作用。Cvx刺激洗涤后的血小板产生肌醇磷酸酯，这一过程独立于环氧化酶途径、血小板活化因子的形成以及ADP释放，但环磷酸腺苷形成的刺激物前列环素（前列腺素I2）会抑制其对血小板和PLC活化的作用。动力学分析表明，在用Cvx刺激血小板后15秒，肌醇1,4,5 -三磷酸的形成达到最大值，并持续至少5分钟。硫酸新霉素（10 mM）可与磷脂酰肌醇4 -磷酸和磷脂酰肌醇4,5 -二磷酸结合，减少肌醇磷酸酯的产生，部分阻止高浓度Cvx（10 nM）诱导的血小板聚集，并消除凝血酶（2单位/毫升）和稳定的前列腺素H2类似物U46619（1 microM）诱导的血小板聚集和肌醇磷酸酯形成。与硫酸新霉素不同，Na2SO4对所有测试的激动剂均无显著影响。得出的结论是，Cvx诱导的血小板活化部分由PLC介导，并且还涉及其他机制。