Kubová H, Mares P
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Physiol Res. 1993;42(5):361-4.
Two doses of alprazolam (0.1 and 0.5 mg.kg-1) were tested against a model of human absences--rhythmic EEG activity elicited by low doses of pentylenetetrazol (35 mg.kg-1)--in 10 unrestrained rats with implanted cortical electrodes. Alprazolam delayed the onset of epileptic EEG activity, decreased the number of rhythmic episodes and shortened the total duration of rhythmic activity in a dose-dependent manner. The average duration of episodes of rhythmic activity remained unchanged; other benzodiazepines studied previously were able to influence this measure.
在10只植入皮层电极的无束缚大鼠中，针对人类失神模型——低剂量戊四氮（35mg·kg-1）诱发的节律性脑电图活动，测试了两剂阿普唑仑（0.1和0.5mg·kg-1）。阿普唑仑以剂量依赖的方式延迟了癫痫性脑电图活动的发作，减少了节律性发作的次数，并缩短了节律性活动的总持续时间。节律性活动发作的平均持续时间保持不变；先前研究的其他苯二氮䓬类药物能够影响这一指标。
