Schenk K E, Biamino G, Schröder R
Klin Wochenschr. 1975 Dec 1;53(23):1133-4. doi: 10.1007/BF01614283.
The haemodynamic effects of intravenous injections of furosemide and ethacrynic acid were studied in 12 patients during rest and exercise. Cardiac output, heart rate and arterial blood pressure showed no significant changes after injection of furosemide or ethacrynic acid. Few minutes after injection of furosemide there were significant falls of pulmonary artery diastolic pressure and right atrial pressure, whereas no changes were seen after injection of ethacrynic acid. This initial effect of furosemide apparently is of primarily vascular origin, causing an increased peripheral venous capacitance. Ethacrynic acid failed to exhibit any direct vascular effect.
在12例患者静息和运动状态下研究了静脉注射呋塞米和依他尼酸的血流动力学效应。注射呋塞米或依他尼酸后，心输出量、心率和动脉血压均无显著变化。注射呋塞米几分钟后，肺动脉舒张压和右心房压力显著下降，而注射依他尼酸后未见变化。呋塞米的这种初始效应显然主要源于血管，导致外周静脉容量增加。依他尼酸未表现出任何直接的血管效应。
