Keeling D M, Isenberg D A
Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.
Blood Rev. 1993 Dec;7(4):199-207. doi: 10.1016/0268-960x(93)90006-p.
Haematological involvement is common in systemic lupus erythematosus (SLE). Whilst anaemia is most often due to chronic disease, other causes such as autoimmune haemolytic anaemia and hypoplastic anaemia need to be considered. The increased risk of infection in patients with SLE is due in part to changes in the white blood cells though treatments do not yet aim to modify these. Thrombocytopenia occurs frequently and is almost invariably autoimmune. It is often of little consequence, but may occasionally be severe and serious, requiring aggressive treatment. Patients with SLE have an increased risk of thrombosis, increased further in the presence of antiphospholipid antibodies (aPL). Changes in the haemostatic system and new insights into the nature of aPL are described.
血液系统受累在系统性红斑狼疮（SLE）中很常见。虽然贫血最常见的原因是慢性病，但也需要考虑其他原因，如自身免疫性溶血性贫血和再生障碍性贫血。SLE患者感染风险增加部分归因于白细胞的变化，不过目前的治疗尚未旨在改善这些变化。血小板减少症经常发生，几乎都是自身免疫性的。它通常影响不大，但偶尔可能很严重，需要积极治疗。SLE患者发生血栓形成的风险增加，在存在抗磷脂抗体（aPL）时风险进一步增加。本文描述了止血系统的变化以及对aPL本质的新见解。
