[Transplantation of vital islands of Langerhans in diabetic animal recipients].

Pancreatic islets of 300 g-Lewis-rats have been transplanted to 200 g streptozotocin-diabetic rats after preparation by manual-dissection method and by the Ficoll-method. The transplantation of more than 500 intact pancreatic islets into the peritoneal cavity of streptozotocin-diabetic-Lewis-rats results in a significant reduction of hyperglycemia, an increase of insulin output and a restoration of weight gain. It is suggested, that it is best to use the glucose-tolerance-test for interpretation of insulin-output and insulin-effect.