Herzer J A, Falke K, Schulte H D, Krian A, Rosenbauer K A, Bircks W
Langenbecks Arch Chir. 1975;Suppl:87-92.
Twelve hours partial extracorporeal circulation using the GEDL was carried out in sheep with experimental pulmonary insufficiency. The maximal O2-transfer was 53,8 ccm/min/m2 membrane surface at blood flows of 2 and 3 1/min. The CO2-transfer was nearly 30 ccm/min/m2 if the pCO2 was within the normal range. There was evidence, that the O2-transfer decreases during prolonged perfusion. Scanning-electron-microscopic studies revealed a thickening of the membrane with protein and cell-fragments which were thought to be the reason for the observed decrease in O2-transfer.
在患有实验性肺功能不全的绵羊身上，使用GEDL进行了12小时的部分体外循环。在血流量为2和3升/分钟时，最大氧转移量为53.8立方厘米/分钟/平方米膜表面积。如果pCO2在正常范围内，二氧化碳转移量接近30立方厘米/分钟/平方米。有证据表明，在长时间灌注过程中氧转移量会下降。扫描电子显微镜研究显示，膜因蛋白质和细胞碎片而增厚，这被认为是观察到的氧转移量下降的原因。
