Arias P, Goroll D, Convertini V, Jarry H, Wuttke W
Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Brain Res. 1994 Jan 21;634(2):325-7. doi: 10.1016/0006-8993(94)91937-2.
Taurine (Tau), a putative inhibitory amino acid neurotransmitter, has been shown to inhibit luteinizing hormone (LH) release in vivo. We investigated the effect of this amino acid on LH secretion by cultured anterior pituitary cells. A 5-h incubation with Tau (10(-3)-10(-8) M) did not affect basal or LH-releasing hormone (LHRH)-stimulated LH release. Basal LHRH release from superfused mediobasal hypothalamic fragments was not affected by Tau (10(-3) M). However, this substance clearly diminished LHRH release after stimulation with KCl (50 mM) or N-methyl-D-aspartate (10(-4) M). It is concluded that Tau may exert an inhibitory effect on LH secretion acting at the hypothalamic level.
牛磺酸（Tau）是一种假定的抑制性氨基酸神经递质，已被证明在体内可抑制促黄体生成素（LH）的释放。我们研究了这种氨基酸对培养的垂体前叶细胞LH分泌的影响。用Tau（10⁻³ - 10⁻⁸ M）孵育5小时，对基础或促性腺激素释放激素（LHRH）刺激的LH释放均无影响。从灌流的下丘脑中间基底部碎片释放的基础LHRH不受Tau（10⁻³ M）的影响。然而，在用氯化钾（50 mM）或N-甲基-D-天冬氨酸（10⁻⁴ M）刺激后，这种物质明显减少了LHRH的释放。得出的结论是，Tau可能在下丘脑水平发挥对LH分泌的抑制作用。
