Krebs M O, Kemel M L, Gauchy C, Desban M, Glowinski J
Chaire de Neuropharmacologie, INSERM U114, Collège de France 11, Paris.
Brain Res. 1994 Jan 21;634(2):345-8. doi: 10.1016/0006-8993(94)91941-0.
In two areas of the rat striatum, the in vitro N-methyl-D-aspartate (NMDA, 50 microM)-evoked release of [3H]dopamine was studied in the presence of bicuculline (5 and 50 microM), an antagonist of GABAA receptors. The responses observed with the higher concentration (50 microM) is compatible with an antagonistic activity of bicuculline on NMDA receptor, as recently reported by Wright and Nowak.
在大鼠纹状体的两个区域，研究了在GABAA受体拮抗剂荷包牡丹碱（5和50微摩尔）存在的情况下，体外N-甲基-D-天冬氨酸（NMDA，50微摩尔）诱发的[3H]多巴胺释放。如Wright和Nowak最近所报道的，较高浓度（50微摩尔）时观察到的反应与荷包牡丹碱对NMDA受体的拮抗活性相符。
