Matthew A D, Gonzalez R, Jeffords D, Pinto M H
J Urol. 1978 Oct;120(4):442-3. doi: 10.1016/s0022-5347(17)57222-5.
Of 40 patients who underwent transurethral prostatectomy without receiving antimicrobial chemoprophylaxis 13 had significant bacteriuria at some time in the postoperative course. Of 47 patients given nitrofurantoin none of the 42 for whom culture results were available had bacteriuria. This difference between the 2 groups is statistically significant (p less than 0.01). Nitrofurantoin prevents post-prostatectomy bacteriuria and has a theoretical advantage over agents such as the cephalosporins in that its action is limited to the urinary tract.
在40例未接受抗菌药物预防性化疗而接受经尿道前列腺切除术的患者中，13例在术后病程中的某些时候出现了显著菌尿。在47例给予呋喃妥因的患者中，42例有培养结果者均无菌尿。两组之间的这种差异具有统计学意义（p小于0.01）。呋喃妥因可预防前列腺切除术后菌尿，与头孢菌素等药物相比具有理论优势，因为其作用仅限于尿路。
