Uluitu M, Oancea C, Petec G H, Vicol L
Physiologie. 1975;12(2):113-7.
The researches were carried out on two groups of children: normals and with behavior disturbances. The serum cationic state was determined by an original method, using heparin as cautions exchanger in physiological pH, and the protein reactivity; the electrophoretic mobility of serum proteins at pH 7.4; total soduim and serum proteins. The obtained results show that serum proteins in children with behavior disturbances differ from those of normals, having: 1) smaller number of serotonin-fixing sites, 2) higher strength interaction between the serotonin and proteins, 3) lower resistance to the denaturant agents which has as a consequence the increase of cationic activity in the serum, and an increased electrophoretic mobility. The data are discussed and interpreted as perturbations in the electrolytes exchange (Na+, especially) in the integration centres of the autonomic functions.
正常儿童和有行为障碍的儿童。血清阳离子状态采用一种原始方法测定，该方法在生理pH值下使用肝素作为阳离子交换剂，并测定蛋白质反应性、pH值为7.4时血清蛋白的电泳迁移率、总钠含量和血清蛋白。所得结果表明，有行为障碍的儿童血清蛋白与正常儿童不同，表现为：1）血清素结合位点数量较少；2）血清素与蛋白质之间的相互作用强度较高；3）对变性剂的抵抗力较低，结果导致血清中阳离子活性增加，电泳迁移率升高。对这些数据进行了讨论，并解释为自主功能整合中心电解质交换（尤其是Na+）的扰动。
