Klingenberg M
Institute for Physical Biochemistry, University of Munich, Germany.
J Bioenerg Biomembr. 1993 Oct;25(5):447-57. doi: 10.1007/BF01108402.
A concise review is given of the research in our laboratory on the ADP/ATP carrier (AAC) and the uncoupling protein (UCP). Although homologous proteins, their widely different functions and contrasts are stressed. The pioneer role of research on the AAC, not only for the mitochondrial but also for other carriers, and the present state of their structure-function relationship is reviewed. The function of UCP as a highly regulated H+ carrier is described in contrast to the largely unregulated ADP/ATP exchange in AAC. General principles of carrier catalysis as derived from studies on the AAC and UCP are elucidated.
本文简要回顾了我们实验室对ADP/ATP载体（AAC）和解偶联蛋白（UCP）的研究。尽管它们是同源蛋白，但强调了它们截然不同的功能和差异。回顾了AAC研究的先驱作用，不仅对线粒体载体，而且对其他载体，以及它们结构-功能关系的现状。与AAC中基本不受调控的ADP/ATP交换形成对比，描述了UCP作为高度调控的H⁺载体的功能。阐明了从对AAC和UCP的研究中得出的载体催化的一般原理。
