香豆素在前列腺癌和乳腺癌模型中的抗肿瘤活性。
Antitumour activity of coumarin in prostate and mammary cancer models.
作者信息
von Angerer E, Kager M, Maucher A
机构信息
Universität Regensburg, Institut für Pharmazie, Germany.
出版信息
J Cancer Res Clin Oncol. 1994;120 Suppl(Suppl 1):S14-6. doi: 10.1007/BF01377116.
The antineoplastic and antimetastatic activities of coumarin were evaluated in transplanted prostate tumours of the rat. The growth of Noble Nb-R prostate tumours was strongly inhibited by coumarin (40 mg/kg; administered three times per week), whereas the hormonally more sensitive Dunning R3327-G rat prostate carcinoma did not respond. Coumarin was also shown to possess antimetastatic activity in a Dunning R3327-MatLu tumour model. The number of lung metastases was reduced significantly by 40%-50% following the administration of coumarin (40 mg daily). Preliminary data from experiments with rats bearing DMBA-induced mammary carcinomas showed that these tumours are as sensitive to coumarin as Noble-R-prostate tumours.
在大鼠移植性前列腺肿瘤中评估了香豆素的抗肿瘤和抗转移活性。香豆素（40毫克/千克；每周给药三次）强烈抑制了诺布尔Nb-R前列腺肿瘤的生长，而激素敏感性更高的邓宁R3327-G大鼠前列腺癌则无反应。在邓宁R3327-MatLu肿瘤模型中，香豆素也显示出抗转移活性。给予香豆素（每日40毫克）后，肺转移灶数量显著减少40%-50%。携带二甲基苯并蒽诱导的乳腺癌大鼠的实验初步数据表明，这些肿瘤对香豆素的敏感性与诺布尔-R-前列腺肿瘤相同。
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