Landström M, Damber J E, Bergh A, Tomic R
Department of Physiology, University of Umeå, Sweden.
J Cancer Res Clin Oncol. 1992;118(1):30-4. doi: 10.1007/BF01192308.
The present study was undertaken to investigate to what extent the oestrogen-induced effects on growth and morphology of the Dunning R3327 rat prostatic adenocarcinoma are dose-dependent. Castrated and testosterone-supplemented rats were used in order to study effects of increasing doses of oestrogens on the tumour. It was found that the lowest dose of oestradiol-17 beta that reduced the overall growth, the volume density of the epithelium and epithelial cell area in Dunning R3327 prostatic tumours is 10 micrograms given as daily injections. Higher oestrogen doses (50 micrograms, 200 micrograms, and 500 micrograms), in addition to reducing the volume of tumour epithelium, also induced an increase of the volume density of tumour stroma. The area of stroma cell nuclei was increased by 50 micrograms and 200 micrograms oestradiol-17 beta. These observation, may indicate that the lowest effective oestrogen dose is different in the epithelium and stroma of Dunning tumours and that large doses of oestrogen stimulate the stromal compartment. This stimulatory effect did not influence the inhibitory effects seen on the overall growth of the tumour and on the tumor epithelium.
本研究旨在探讨雌激素对Dunning R3327大鼠前列腺腺癌生长和形态的影响在何种程度上呈剂量依赖性。使用去势并补充睾酮的大鼠来研究递增剂量雌激素对肿瘤的影响。结果发现，每天注射10微克的17β-雌二醇是降低Dunning R3327前列腺肿瘤总体生长、上皮组织体积密度和上皮细胞面积的最低剂量。更高剂量的雌激素（50微克、200微克和500微克），除了减少肿瘤上皮组织的体积外，还会导致肿瘤基质的体积密度增加。50微克和200微克的17β-雌二醇会使基质细胞核面积增加。这些观察结果可能表明，Dunning肿瘤上皮组织和基质中最低有效雌激素剂量不同，且大剂量雌激素会刺激基质部分。这种刺激作用并未影响对肿瘤总体生长和肿瘤上皮组织的抑制作用。
