磺胺醋酰药物硝酸铜（II）的合成与光谱研究。[Cu（磺胺醋酰）₂（NO₃）₂]的晶体结构。抗菌研究。

Synthesis and spectroscopy studies of copper(II) nitrate of sulfacetamide drug. Crystal structure of [Cu(sulfacetamide)2(NO3)2]. Antibacterial studies.

作者信息

Blasco F, Ortiz R, Perelló L, Borrás J, Amigó J, Debaerdemaeker T

机构信息

Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Valencia, Burjassot, Spain.

出版信息

J Inorg Biochem. 1994 Feb 1;53(2):117-26. doi: 10.1016/0162-0134(94)85026-7.

DOI:10.1016/0162-0134(94)85026-7

PMID:8133250

Abstract

The structural spectroscopic, and thermal properties of a complex of sulfacetamide (Hsacm) with Cu(II) have been investigated. The complex [Cu(Hsacm)2(NO3)2] crystallizes in the monoclinic system, space group P2(1)/n. The cell dimensions are a = 7.696(7) A, b = 8.017(7) A, c = 19.230(10), beta = 110.80(1) degree, V = 1109(1) A3, Z = 2, and Dx = 1.84 g/cm3. The structure was refined to R = 0.0776. Cu(Hsacm)2(NO3)2 molecules form a long polymeric chain extended along the b-axis. The copper(II) coordinated geometry is tetragonally distorted octahedral with two amino nitrogens from Hsacm and two oxygens from nitrato anions in the basal plane and two acetamido oxygens from neighbor Hsacm molecules in the apical position. Each sulfacetamide, acting as a bidentate ligand, links two Cu(II) ions as a bridge through the Namino and the Oacetamido atoms. The complex proved to possess higher bacteriostatic activity than the corresponding ligand.

摘要

已对磺胺醋酰（Hsacm）与铜（II）形成的配合物的结构、光谱和热性质进行了研究。配合物[Cu(Hsacm)2(NO3)2]以单斜晶系结晶，空间群为P2(1)/n。晶胞参数为a = 7.696(7) Å，b = 8.017(7) Å，c = 19.230(10)，β = 110.80(1)°，V = 1109(1) Å3，Z = 2，Dx = 1.84 g/cm3。结构精修后R = 0.0776。Cu(Hsacm)2(NO3)2分子形成沿b轴延伸的长聚合物链。铜（II）的配位几何形状为四方畸变八面体，基面中有来自Hsacm的两个氨基氮原子和来自硝酸根阴离子的两个氧原子，顶端位置有来自相邻Hsacm分子的两个乙酰氨基氧原子。每个磺胺醋酰作为双齿配体，通过氨基氮原子和乙酰氨基氧原子作为桥连接两个铜（II）离子。该配合物被证明具有比相应配体更高的抑菌活性。