Sharara A I, Hillsley R E, Wax T D, Rosse W F
Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710.
South Med J. 1994 Mar;87(3):397-9. doi: 10.1097/00007611-199403000-00019.
This report describes a patient with severe unexplained recurrent hemolytic anemia and congestive heart failure. Donath-Landsteiner antibodies, suggestive of paroxysmal cold hemoglobinuria (PCH), were detected. On postmortem examination, a diagnosis of non-Hodgkin's lymphoma, primarily involving the heart, was made. This previously undescribed association expands on the clinical and serologic spectrum of non-Hodgkin's lymphoma and PCH. Unexplained hemolytic anemia in the elderly should raise the suspicion of an underlying lymphoproliferative disorder.
本报告描述了一名患有严重不明原因复发性溶血性贫血和充血性心力衰竭的患者。检测到提示阵发性冷血红蛋白尿（PCH）的多纳-兰德斯泰纳抗体。尸检诊断为非霍奇金淋巴瘤，主要累及心脏。这种先前未描述的关联扩展了非霍奇金淋巴瘤和PCH的临床和血清学谱。老年人不明原因的溶血性贫血应引起对潜在淋巴增殖性疾病的怀疑。
