Mellon C D, Umar F, Hanson M L
University of Utah School of Medicine, Salt Lake City 84103.
Am J Med Genet. 1993 Dec 15;48(4):179-83. doi: 10.1002/ajmg.1320480403.
Stuttering is a broad behavioral phenotype with an adult prevalence of 0.7-1.0%. Family, twin, and segregation studies all indicate that stuttering has a large genetic component to its etiology. The relatively simple phenotype, the early onset, and the apparent rarity of phenocopies of adult stuttering all make stuttering a promising model for the study of the genetics of broad behavioral phenotypes.
口吃是一种广泛的行为表型,成年人中的患病率为0.7%-1.0%。家族、双胞胎和分离分析均表明,口吃在病因学上有很大的遗传成分。相对简单的表型、发病早以及成人口吃表型模拟的明显罕见性,都使口吃成为研究广泛行为表型遗传学的一个有前景的模型。