Verkhovtseva T P, Lur'e L M, Levitov M M
Antibiotiki. 1975 Oct;20(10):876-80.
Substances toxic for biosynthesis of penicillin accumulated in the medium at the end of the process during penicillin fermentation. Accumulation of such substances was associated with the mycelium autolysis. Addition of nutrient substances as soon as they are consumed prevented autolysis of the mycelium and accumulation of the toxic metabolites.
在青霉素发酵过程结束时，对青霉素生物合成有毒的物质在培养基中积累。这些物质的积累与菌丝体自溶有关。一旦营养物质被消耗就添加营养物质可防止菌丝体自溶和有毒代谢产物的积累。
