Apple D J, Wyhinny G J, Goldberg M F, Polley E H, Bizzell J W
Arch Ophthalmol. 1976 Jan;94(1):137-44. doi: 10.1001/archopht.1976.03910030071017.
Eight rhesus monkeys were photocoagulated with varying intensities of argon laser energy to determine the effects on the retinal nerve fiber layer. Photocoagulation of arterioles and venules always resulted in largely irreversible and permanent perivascular axonal destruction. Photocoagulation of areas free of major vessels showed variable responses to identical dosages, ranging from minimal destruction of the outer part of the retina to full-thickness destruction involving the nerve fiber layer. Variations in retinal thickness, vascularity, pigment epithelial pigmentation, and focus of the laser beam are responsible for differences in severity of each burn. Even when major vessels are avoided, it is impossible to predict accurately the degree of damage. However, our studies suggest that much of the initial damage is extracellular, sparing nerve fiber layer axons. Therefore, some acute damage might be reversible following resorption of the edema.
八只恒河猴接受了不同强度的氩激光能量光凝，以确定对视网膜神经纤维层的影响。小动脉和小静脉的光凝总是导致血管周围轴突在很大程度上不可逆转和永久性的破坏。对无主要血管区域进行光凝时，相同剂量会产生不同反应，从视网膜外层的轻微破坏到累及神经纤维层的全层破坏不等。视网膜厚度、血管分布、色素上皮色素沉着以及激光束焦点的变化导致了每次灼伤严重程度的差异。即使避开主要血管，也无法准确预测损伤程度。然而，我们的研究表明，许多初始损伤是细胞外的，神经纤维层轴突未受影响。因此，水肿吸收后，一些急性损伤可能是可逆的。
