Olszewski E
Arch Otolaryngol. 1976 Feb;102(2):65-70. doi: 10.1001/archotol.1976.00780070043001.
Injection methods were used for the study of the blood vascular system in 50 specimens from total or subtotal laryngectomy in patients with extensive cancer of the larynx, and in 24 normal postmortem larynges. All specimens were injected via the superior laryngeal arteries. A silicone rubber technique was found to be the most suitable for the aims of this study. A chaotic distribution of abnormal vessels that differ in shape, a rich neovascular network within the tumor, and capillary hypertrophy in its vicinity are the main features of the blood vascular system in laryngeal cancer. The results obtained indicate great tumor-angiogenic ability that can be indirectly explained by action of an angiogenesis factor diffusing from cancer cells. This may open new possibilities for the treatment of carcinoma of the larynx based on anti-angiogenesis.
采用注射方法，对50例喉广泛癌患者全喉或次全喉切除标本以及24例正常喉尸检标本的血管系统进行了研究。所有标本均经喉上动脉注射。结果发现，硅橡胶技术最适合本研究目的。形状各异的异常血管呈杂乱分布、肿瘤内丰富的新生血管网络及其周边的毛细血管肥大是喉癌血管系统的主要特征。所得结果表明肿瘤具有很强的血管生成能力，这可能是由癌细胞扩散的血管生成因子的作用间接解释的。这可能为基于抗血管生成的喉癌治疗开辟新的途径。
