25-羟基胆钙化醇在一种新大陆猴体内的转运
The transport of 25-hydroxycholecalciferol in a New World monkey.
作者信息
Hay A W
出版信息
Biochem J. 1975 Oct;151(1):193-6. doi: 10.1042/bj1510193.
Abstract
Albumin is responsible for the transport of 25-hydroxycholecalciferol in the Capuchin monkey. This was confirmed by gel filtration, analytical polyacrylamide-disc-gel electrophoresis, polyacrylamide-gel isoelectric focusing and a competitive protein-binding assay. Association constants of the serum transport proteins of a New and an Old World monkey towards 25-hydroxycholecalciferol were calculated; the transport protein in the New World monkey has a lower affinity for the vitamin D metabolite than the transport protein in the Old World primate.
摘要
白蛋白负责卷尾猴体内25-羟基胆钙化醇的运输。这通过凝胶过滤、分析型聚丙烯酰胺圆盘凝胶电泳、聚丙烯酰胺凝胶等电聚焦以及竞争性蛋白结合测定得以证实。计算了一种新大陆猴和一种旧大陆猴血清转运蛋白与25-羟基胆钙化醇的结合常数；新大陆猴体内的转运蛋白对维生素D代谢物的亲和力低于旧大陆灵长类动物体内的转运蛋白。
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