García Pascual I J, González Ruiz J M
Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Salamanca.
An Med Interna. 1993 Oct;10(10):473-8.
The aim of this study was to know about the plasmatic variations of insulin and its potential origin in the obesity with or without abnormal tolerance to glucose. Obese patients with normal tolerance to glucose showed normal and hypersecretion of insulin during fasting and after oral overdose of glucose (OOG). Fasting hyperinsulinism in patients with normal secretion of insulin was due to a decrease in its hepatic clearance, whereas in patients with hypersecretion, it was due mainly to insulin hypersecretion. Most of the obese patients with glucose intolerance showed hypersecretion of insulin during fasting and after OOG, being their basal hyperinsulinism due to insulinic secretion. After the OOG, the hyperinsulinism due to insulin hypersecretion and/or a decrease in its hepatic clearance. In addition, we observed an inverse correlation between body mass index and obese patients with normal tolerance to glucose.
本研究的目的是了解胰岛素的血浆变化及其在伴有或不伴有葡萄糖耐量异常的肥胖症中的潜在来源。葡萄糖耐量正常的肥胖患者在空腹时以及口服过量葡萄糖（OOG）后胰岛素分泌正常且分泌过多。胰岛素分泌正常的患者空腹高胰岛素血症是由于其肝脏清除率降低，而分泌过多的患者则主要是由于胰岛素分泌过多。大多数葡萄糖不耐受的肥胖患者在空腹时以及OOG后胰岛素分泌过多，其基础高胰岛素血症是由于胰岛素分泌所致。OOG后，高胰岛素血症是由于胰岛素分泌过多和/或其肝脏清除率降低。此外，我们观察到体重指数与葡萄糖耐量正常的肥胖患者之间呈负相关。
