肯尼亚西部关于人类免疫缺陷病毒1型（HIV-1）感染作为结核病和麻风病危险因素的病例对照研究。

A case control study on human immunodeficiency virus-1 (HIV-1) infection as a risk factor for tuberculosis and leprosy in western Kenya.

作者信息

Orege P A, Fine P E, Lucas S B, Obura M, Okelo C, Okuku P, Were M

机构信息

Kenya Medical Research Institute, Alupe Leprosy and Skin Diseases Research Centre, Busia.

出版信息

Tuber Lung Dis. 1993 Dec;74(6):377-81. doi: 10.1016/0962-8479(93)90080-H.

DOI:10.1016/0962-8479(93)90080-H

PMID:8136490

Abstract

A case control study was undertaken in Western Kenya from April 1989 to August 1990 to evaluate HIV-1 infection as a risk factor for tuberculosis and leprosy. The study involved 144 newly diagnosed sputum smear positive tuberculosis cases with 432 age, sex and neighbourhood-matched controls, and 132 diagnosed leprosy cases with 384 matched controls. Odds ratios obtained by conditional logistic regression (matched) analysis were 4.9 (95% CI 2.6, 6.8), and 1.8 (95% CI 0.9, 3.2), for the association between HIV-1 and tuberculosis and leprosy respectively. Approximately 31% of tuberculosis cases among males, and 11% of cases among females, were attributable to HIV infection.

摘要

1989年4月至1990年8月在肯尼亚西部开展了一项病例对照研究，以评估HIV-1感染作为结核病和麻风病的危险因素。该研究纳入了144例新诊断的痰涂片阳性结核病病例以及432例年龄、性别和邻里匹配的对照，还有132例诊断为麻风病的病例以及384例匹配的对照。通过条件逻辑回归（匹配）分析得出的HIV-1与结核病和麻风病之间关联的比值比分别为4.9（95%可信区间2.6, 6.8）和1.8（95%可信区间0.9, 3.2）。男性结核病病例中约31%、女性病例中约11%可归因于HIV感染。