Ruiz E, Osorio E, Ortega E
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Spain.
Biochem Mol Biol Int. 1993 Dec;31(5):889-95.
To evaluate whether the median eminence (ME) is a site of action of opioids on gonadotropin secretion, we injected naloxone into the ME in male rats and measured LH and FSH serum levels. Injection into the ME of either 0.5 or 1 microgram of naloxone significantly decreased serum LH levels 10 and 30 min postinjection. A dose of 0.1 microgram had not effect. Naloxone at the doses used had no significant effect on FSH secretion. From these data it can be concluded that endogenous opioids exert a tonic stimulation on LH secretion under our experimental conditions.
为评估正中隆起（ME）是否为阿片类药物作用于促性腺激素分泌的位点，我们向雄性大鼠的正中隆起注射纳洛酮，并测量血清促黄体生成素（LH）和促卵泡生成素（FSH）水平。向正中隆起注射0.5微克或1微克纳洛酮后10分钟和30分钟，血清LH水平显著降低。0.1微克的剂量则无此作用。所用剂量的纳洛酮对FSH分泌无显著影响。从这些数据可以得出结论，在我们的实验条件下，内源性阿片类物质对LH分泌有紧张性刺激作用。
