van den Berg H, Gerritsen E J, Haraldsson A, Vossen J M
Het Emma Kinderziekenhuis/Het Kinder AMC, Amsterdam, The Netherlands.
Bone Marrow Transplant. 1993 Dec;12(6):615-9.
The material from 59 and 134 cerebrospinal fluid (CSF) samples, taken in the week prior to grafting and during the first 100 days after grafting respectively, were examined from 37 children undergoing allogeneic BMT. All CSF samples were obtained from lumbar punctures performed for regular administration of methotrexate (MTX). Prior to bone marrow transplantation (BMT) the increased protein levels and increased cell numbers noted in two children were probably caused by arachnoiditis from MTX administration 5 days earlier. After BMT, cell numbers increased in 54% of children and in 27% of children increased protein levels were found in the CSF. No correlation with clinical findings including neurological findings, infections and prior intrathecal MTX administration was found. The CSF changes observed are probably induced by the conditioning regimen (i.e. cyclophosphamide and total body irradiation). We conclude that the normal ranges for CSF components seen in healthy individuals do not apply in BMT recipients during the first 100 days after grafting.
分别从37例接受异基因骨髓移植（BMT）的儿童中获取了59份和134份脑脊液（CSF）样本，这些样本分别在移植前一周和移植后的前100天内采集。所有脑脊液样本均通过腰椎穿刺获取，用于常规给予甲氨蝶呤（MTX）。在骨髓移植（BMT）前，两名儿童脑脊液中蛋白质水平升高和细胞数量增加，可能是由于5天前给予MTX导致的蛛网膜炎。BMT后，54%的儿童脑脊液细胞数量增加，27%的儿童脑脊液蛋白质水平升高。未发现与包括神经学表现、感染及先前鞘内注射MTX在内的临床发现存在相关性。观察到的脑脊液变化可能是由预处理方案（即环磷酰胺和全身照射）引起的。我们得出结论，健康个体中脑脊液成分的正常范围不适用于移植后前100天内的BMT受者。
