Avalos B R, Copelan E A
Department of Internal Medicine, Ohio State University, Columbus 43210.
Bone Marrow Transplant. 1993 Dec;12(6):665-7.
We report a case of sustained disease-free survival following second autologous marrow transplantation (BMT) in a patient with Hodgkin's lymphoma which had recurred following several conventional chemotherapy regimens as well as a prior autologous transplant. The initial autologous BMT was performed in fourth complete remission and followed high-dose cyclophosphamide, etoposide and thiotepa. The disease recurred 8 months later and the patient underwent a second ABMT following conditioning with busulfan and cyclophosphamide 1 year after his first transplant. Aside from slow engraftment, his course was uncomplicated. This patient remains in complete remission more than 4 years and 6 months following the second transplantation. This case demonstrates that second autologous transplantation can result in sustained disease-free survival in individuals with Hodgkin's disease with recurrence following initial transplantation.
我们报告了1例霍奇金淋巴瘤患者在接受了几种传统化疗方案以及1次自体移植后复发，随后进行第二次自体骨髓移植（BMT）并实现持续无病生存的病例。首次自体BMT是在第4次完全缓解期进行的，采用了大剂量环磷酰胺、依托泊苷和噻替派。8个月后疾病复发，患者在首次移植1年后接受了白消安和环磷酰胺预处理后的第二次自体骨髓移植（ABMT）。除了植入缓慢外，他的病程没有并发症。该患者在第二次移植后4年6个月以上仍处于完全缓解状态。该病例表明，第二次自体移植可使初次移植后复发的霍奇金病患者实现持续无病生存。
