朊病毒疾病的转基因学与细胞生物学：朊病毒蛋白（PrPSc）合成及多样性研究

Transgenetics and cell biology of prion diseases: investigations of PrPSc synthesis and diversity.

作者信息

Prusiner S B

机构信息

Department of Neurology, University of California, San Francisco.

出版信息

Br Med Bull. 1993 Oct;49(4):873-912. doi: 10.1093/oxfordjournals.bmb.a072652.

DOI:10.1093/oxfordjournals.bmb.a072652

PMID:8137134

Abstract

Studies with Tg mice have contributed a wealth of new knowledge about the synthesis of prion particles and the pathogenesis of both the genetic and infectious forms of the prion diseases. Transgenetic studies argue persuasively that the 'species barrier' is due to differences in PrP gene sequences among mammals.

摘要

对转基因小鼠的研究为朊病毒颗粒的合成以及朊病毒疾病的遗传形式和感染形式的发病机制提供了大量新知识。转基因研究有力地表明，“种间屏障”是由于哺乳动物之间PrP基因序列的差异所致。