Hondo H, Yonezawa Y, Nakahara T, Nakamura K, Hirano M, Uchimura H, Tashiro N
Laboratory of Neurochemistry, Hizen National Mental Hospital, Kanzaki Saga, Japan.
Brain Res. 1994 Jan 7;633(1-2):337-42. doi: 10.1016/0006-8993(94)91558-x.
The effect of phencyclidine (PCP) on the extracellular dopamine levels in the rat prefrontal cortex was investigated using an in vivo brain dialysis technique. PCP increased extracellular dopamine levels in the prefrontal cortex of freely-moving rats after the systemic (7.5 mg/kg i.p.) or the local injection (100 microM and 500 microM). The local injection of MK-801, which is a more selective and potent NMDA receptor antagonist than PCP also increased the extracellular dopamine levels (from 10 microM to 100 microM). These results suggest that part of the effect of PCP is attributable to its antagonist effect on the NMDA receptor.
采用体内脑透析技术研究了苯环己哌啶（PCP）对大鼠前额叶皮质细胞外多巴胺水平的影响。在全身注射（腹腔注射7.5mg/kg）或局部注射（100μM和500μM）后，PCP增加了自由活动大鼠前额叶皮质的细胞外多巴胺水平。局部注射MK-801（一种比PCP更具选择性和强效的N-甲基-D-天冬氨酸受体拮抗剂）也增加了细胞外多巴胺水平（从10μM增至100μM）。这些结果表明，PCP的部分作用归因于其对N-甲基-D-天冬氨酸受体的拮抗作用。
