Xu F J, Yu Y H, Daly L, Anselmino L, Hass G M, Berchuck A, Rodriguez G C, Soper J T, Clarke-Pearson D L, Hollis D
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Cancer. 1994 Apr 1;73(7):1855-8. doi: 10.1002/1097-0142(19940401)73:7<1855::aid-cncr2820730713>3.0.co;2-#.
Endometrial carcinoma is generally diagnosed only after the onset of postmenopausal bleeding. Although most patients with Stage I disease can be cured, the prognosis worsens significantly when the tumor is no longer confined to the uterine corpus. Serum CA 125 is elevated in only 10-20% cases of Stage I and II endometrial carcinoma. A serum tumor marker that can detect early stage endometrial cancer might aid in management of the disease.
An OVX1 double-determinant radioimmunoassay was used to detect an epitope on a high-molecular-weight mucinlike glycoprotein found in the sera of 45 patients with endometrial cancer.
Apparently healthy persons had serum OVX1 antigen levels of 2.23 plus or minus 2.48 U/ml (mean +/- standard deviation). Elevated levels of OVX1 antigen (> 7.2 U/ml) were found in 5% of 184 healthy persons and in 64% of 45 patients with endometrial cancer. OVX1 antigen was elevated in 64% of 36 patients with Stage I, 50% of 2 patients with Stage II, 60% of 5 patients with Stage III, and each of 2 patients with Stage IV endometrial cancer, but only 8.6% of 58 patients with endometriosis. Elevation of serum OVX1 was found more frequently in patients with deep myometrial invasion and with poorly differentiated tumors (P < 0.01).
The OVX1 antigen deserves further evaluation as a marker for early detection of endometrial cancers and as a prognostic factor for women with apparent early stage disease.
子宫内膜癌通常在绝经后出血开始后才被诊断出来。虽然大多数I期疾病患者可以治愈，但当肿瘤不再局限于子宫体时，预后会显著恶化。血清CA 125仅在10%-20%的I期和II期子宫内膜癌病例中升高。一种能够检测早期子宫内膜癌的血清肿瘤标志物可能有助于该疾病的管理。
采用OVX1双决定簇放射免疫分析法检测45例子宫内膜癌患者血清中一种高分子量粘蛋白样糖蛋白上的表位。
明显健康者的血清OVX1抗原水平为2.23±2.48 U/ml（平均值±标准差）。在184名健康者中有5%以及45例子宫内膜癌患者中有64%的患者OVX1抗原水平升高（>7.2 U/ml）。36例I期患者中有64%、2例II期患者中有50%、5例III期患者中有60%以及2例IV期子宫内膜癌患者的OVX1抗原均升高，但58例子宫内膜异位症患者中只有8.6%升高。血清OVX1升高在肌层浸润深和肿瘤分化差的患者中更常见（P<0.01）。
OVX1抗原作为早期检测子宫内膜癌的标志物以及明显早期疾病女性的预后因素值得进一步评估。
