烷化剂的药代动力学。
Pharmacokinetics of alkylating agents.
作者信息
Lind M J, Ardiet C
机构信息
Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne.
出版信息
Cancer Surv. 1993;17:157-88.
PMID:8137340
Abstract
Alkylating agents have been used for over 30 years in the treatment of malignant disease. Because of their very reactive nature, studies of their intermediate metabolism have been difficult. However, this is now possible with modern analytical techniques. Further understanding of their metabolism and pharmacokinetics should lead to a more rational use in the clinic.
摘要
烷化剂已用于恶性疾病的治疗逾30年。由于其反应活性很强，对其中间代谢的研究一直很困难。然而，借助现代分析技术现在这已成为可能。对其代谢和药代动力学的进一步了解应能使临床应用更加合理。
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