Miranda M
Biochim Biophys Acta. 1976 Feb 13;422(2):249-53. doi: 10.1016/0005-2744(76)90135-2.
It has been suggested by some authors that during amphibian development, due to the higher glucose-6-phosphate dehydrogenase (EC 1.1.1.49) activity compared to that of 6-phosphogluconate dehydrogenase (EC 1.1.1.43), 6-phosphogluconate could accumulate in the embryo tissues and regulate the channelling of glucose-6-phosphate into glycolysis. Here, on the base of the specific activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glucose-6-phosphate isomerase (EC 5.3.1.9) found in the embryos of Bufo bufo during development, it is discussed whether 6-phosphogluconate can accumulate and play a regulative role on glucose-6-phosphate metabolism in the anuran embryo.
一些作者认为，在两栖动物发育过程中，由于葡萄糖-6-磷酸脱氢酶（EC 1.1.1.49）的活性高于6-磷酸葡萄糖酸脱氢酶（EC 1.1.1.43），6-磷酸葡萄糖酸可能在胚胎组织中积累，并调节葡萄糖-6-磷酸进入糖酵解的途径。在此，根据在中华大蟾蜍胚胎发育过程中发现的葡萄糖-6-磷酸脱氢酶、6-磷酸葡萄糖酸脱氢酶和葡萄糖-6-磷酸异构酶（EC 5.3.1.9）的比活性，讨论了6-磷酸葡萄糖酸是否能在无尾目胚胎中积累并对葡萄糖-6-磷酸代谢发挥调节作用。
