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Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein.

作者信息

Oxvig C, Gleich G J, Sottrup-Jensen L

机构信息

Department of Molecular Biology, University of Aarhus, Denmark.

出版信息

FEBS Lett. 1994 Mar 21;341(2-3):213-7. doi: 10.1016/0014-5793(94)80459-1.

DOI:10.1016/0014-5793(94)80459-1
PMID:8137941
Abstract

Eosinophil granule major basic protein (117 residues) is known to contain free sulfhydryl groups. Here we have located in the amino acid sequence the half-cystine residues present as cysteine, and identified those engaged in disulfide bridges. Of the 9 half-cystine residues, 5 are unpaired cysteines (Cys2, Cys23, Cys42, Cys64, and Cys96), while 4 form disulfides (Cys20-Cys115, and Cys92-Cys107).

摘要

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